Playing on Unlimited

Does anyone else play on this setting? There is a warning popup when you switch, so I have some anxiety, although nothing has happened in my game yet. Is it harmful to the game? What do you think? Not worth the risk?

I play on rotation and I just like to favourite all the Sims so that they don't get culled before I can play them, because I've heard the Sims will disappear from the game after a while if you don't play them.