I've two folders of thesims4 on my computer and my mods not working

@deartwn 

The first is your game files. The second is your user folder. This is normal.

For the mods that are not working if they were in a packed format such as .zip or .rar you need to unpack them. You should always read install instructions where you get them. You write 5000 which make it unlikely that they are all mods. The majority is probably Custom Content (CC). Again read instructions on how to use where you got it.

I've unpack all of it. Yesterday before I'm redownload a game my 5000 mods work. But now it's notworking.So it make me thinking that maybe it's not ploblem because of mods.

@deartwn  Your mods need to go into Documents > Electronic Arts > The Sims 4 > Mods.  The second screenshot shows the files are in Program Files > Electronic Arts, where the game won't be able to read them.

Can I reinstall and set it on drive D? Protect from problem my drive C will full .I've seen someone set on driveD.

@deartwn  Yes, you can, in one of two ways.  You can move the Documents directory to D, which is supported by Windows:

https://www.tenforums.com/tutorials/74952-move-location-documents-folder-windows-10-a.html

Or you can use a symbolic link to point the game to the location on D where you want to store your user data.  This guide was written with an external drive in mind, but it works equally well with an internal one.

https://crinrict.com/blog/2020/02/moving-windows-documents-folder-to-external-drive-via-symbolic-link.html

You can choose any folder on D except for the folder that contains the game's program files, as in, what you see in the first screenshot you posted.  If you choose this option, please back up all your critical Sims 4 files—saves, mods, anything you'd be sad to lose—before proceeding.

I've tried to reinstall but I decied to install on folder documents. So In a picture its show two folders ,my folder on program files have all of files for thesim4 but on document it's have some files missed(I just know it normal). The point is did I install on the correct one because my mod still not working .It's work only script mod.

@deartwn  Why did you install the game into Documents?  That is NOT the correct location and is just asking for problems.

Let's back up here.  When you play Sims 4, you have two Sims 4 folders with two very different sets of data.  One folder contains the game's program files, as in, the data that Origin (or Steam, or the EA App) installs for you.  This is the data for the game itself.  This folder can be anywhere you want it to be, at least in theory.  However, if you put it in Documents, you're risking some serious issues related to how Windows and antivirus programs interact with the Documents directory as a whole.

The second Sims 4 folder contains your user data—saves, saved households and builds, screenshots, etc.—and is always in Documents > Electronic Arts.  You cannot change the location where the game looks for this user folder; you can only move the Documents directory itself or use a symbolic link to point somewhere else.

For now, please move the game's program files to a folder on D, as you wanted before.  Create that folder on D and call it whatever you want (but NOT Documents or Electronic Arts).  Open your Origin game library, right-click on the Sims 4 icon, select Move Game, and choose the folder on D where you want the game to go.  Origin will do the rest.

Once you've done that, open Documents > Electronic Arts > The Sims 4 > Mods and put your mods and custom content inside.  Then open the game and see whether they show up.