Unable to click on anything then game crashes

saraachasauce  When you started the new save file, did you import any version of this same build?  Were you working on the same lot in-game as before?  I ask because the build itself could be broken, and I've seen a few reports of a particular lot being unusable even in a new save.

If this issue follows you to fresh builds on different lots, provide a dxdiag.  Click Windows key-R, enter dxdiag in the run box, wait for the scan to finish, click "Save all information," and save the file to your desktop.  From there, you can attach it to a reply using the paper clip (Attachment) icon included with the other formatting buttons.