@Zoeno3
Clean up apps are one of the worst apps you can use on your Mac, they often get rid of system files that they shouldn't and can potentially render the operating system unstable.
Firstly, right click on the game in your Origin games library and select Repair Game. If your game still won't work manually uninstall Origin, drag the Sims 4 from your Applications folder to the Trash, drag the Sims 4 folder from Documents > Electronic Arts onto your desktop (this is your user data like saves, CC etc.). Empty your Trash, restart your Mac then redownload Origin and Sims 4 then the EPs/SPs/GPs you have.
How's that?