Not opening at all even without mods

Lorilank89 magshilly  If you have any files in ConfigOverride, please delete them.

Otherwise, as a test, please try playing in a clean user folder.  Move the entire Sims 4 folder out of Documents > Electronic Arts and onto your desktop, and when you launch the game, if it launches, a clean folder will spawn with no content.  (Your saves and other content will be intact in the folder you moved but temporarily not read by the game.)  Don't add anything to the new folder yet; just see whether you can get far enough to start a new save and play in live mode for a bit.

If that doesn't help, please provide a dxdiag.  Hit Windows key-R, enter dxdiag in the run box, wait for the scan to finish, click "Save all information," and save the file to your desktop.  From there, you can attach it to a reply using the camera (Insert Media) icon included with the other formatting buttons.