MHS_2003 I hope you have some antivirus running, and you should have Windows Defender at least. Does the game at least start now? If so, but it's crashing, when does it crash? If it's before the Main Menu, try removing your saves folder.
If that doesn't help, or the crash is at any other time (and it happens in a new save too), please provide a dxdiag. Click Windows key-R, enter dxdiag in the run box, wait for the scan to finish, click "Save all information," and save the file to your desktop. From there, you can attach it to a reply using the paper clip (Attachment) icon included with the other formatting buttons.