Game crashing on after adjusting graphics.

My game crashes after I adjust the graphics settings. When I try to reload back in it crashes on the loading screen. I have done this with a new game folder, no mods, but still the same results. I have reinstalled my redistributables, reinstalled my graphics drivers, run repairs, uninstalled and reinstalled the game. But nothing. This is all happening after one of the recent updates. Can't even load into the game.