FeliciaBently Please test without your mods and custom content, as in, move the Mods folder to the desktop and delete localthumbcache.package. You don't need to save your progress; just let me know whether you can get far enough to load a save.
If that doesn't help, please provide a dxdiag. Click Windows key-R, enter dxdiag in the run box, wait for the scan to finish, click "Save all information," and save the file to your desktop. From there, you can attach it to a reply using the paper clip (Attachment) icon included with the other formatting buttons.