Cannot save game or click on any sim or items.

I have updated all my mods. My game is not throwing anymore errors so cannot post last exception there is none.  It seems to randomly happen. I try to save or pause and the game just does nothing. Sims are stuck in place cannot un pause If I wanted too.  Cannot save. Cannot travel Sims still making noises but just stand there. No time passes so I guess that is good.  Any Idea's as to if I missed a mod that is doing this or is game working as instead?